Papers

RESUSCITATION

Hypothermia
Nolan JP, et al.  Therapeutic hypothermia after cardiac arrest.  An advisory statement by the Advancement Life support Task Force of the International Liason commitee on Resuscitation.  Resuscitation.   2003 Jun;57(3):231-5.
Bernard SA, et al.  Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.  New Engl J Med.  2002, 346980: 557-63.

Sepsis
Jones AE, et al.  Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial.  JAMA.  2010;303(8):739-46.
Arnold RC, et al.  Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis.  Shock.  2009;32(1):35-9.
Rivers E, et al.  Early goal-directed therapy in the treatment of severe sepsis and septic shock.   New Engl J Med.  2001;345(19): 1368-77.

Lactate
Jones AE, et al.  Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial.  JAMA.  2010;303(8):739-46.
Arnold RC, et al.  Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis.  Shock.  2009;32(1):35-9.
Lavery RF, et al.  The utility of venous lactate to triage injured patients in the trauma center.   J Am Coll Surg.  2000; 190(6):656-664.
Gallagher EJ, et al.  Agreement between peripheral venous and arterial lactate levels.  Ann Emerg Med.  1997; 29(4): 479-483.
Weil M, et al.  Comparison of blood lactate concentrations in central venous, pulmonary artery, and arterial blood. Crit Care Med. 1987; 15(5):489-90.

Cardiac arrest
Highlights of the 2010 American Heart Association Guidelines for CPR and ECC
Hazinski MF, et al.  Executive Summary, 2010 International Consensus on Cardiopulmonary resuscitation and emergecy cardiovascular care science with treatment recommendations.  Circulation.  2010;122:S250-S275.
Svensson L, et al.  Compression-only CPR or standard CPR in out-of-hospital cardiac arrest.  New Engl J Med.  2010; 363(5):434-42.

CARDIOVASCULAR

Heart Failure
Morrison LK, et al.  Utility of a rapid B-natriuretic peptide assay in differentiating congestive heart failure from lung disease in patients presenting wth dyspnea.  J Am Coll Cardiol.  2002;39(2):202-9.

Syncope
Brignole M, et al.  A new management of syncope: prospective systematic guideline-based evaluation of patients referred urgently to general hospitals.  Eur Heart J. 2006 27(1):76-82.
Quinn J, et al.  Prospective validation of the San Francisco Syncope Rule to predict patients with serious outcomes.  Ann Emerg Med.  2006;47(5):448-54.
Quinn JV, et al.  Derivation of the San Francisco Syncop Rule to predict patients with short-term serious outcomes.  Ann Emerg Med.  2004; 43(2):224-32.
McGee S, et al.  The rational clinical examination.  Is this patient hypovolemic?  JAMA.  1999; 281(11):1022-9.
Koziol-McLain J, et al.  Orthostatic vital signs in emergency department patients.  Ann Emerg Med.  1991 20(6):606-10.

Chest pain
Weber JE, et al.  Validation of a brief observation period for patients with cocaine-associated chest pain.  New Engl J Med.  2003; 348(6):510-7.
Sgarbossa EB, et al.  Electrocardiographic diagnosis of evolving acute myocardial infarction in the presence of left bundle-branch block.  New Engl J Med.  1996;334(8):481-7.

PULMONARY

Pulmonary Embolism
Jaff MR, et al.  Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association.  Circulation 2011; 123:1788-1830.
Kline JA, et al.  Prospective multicenter evaluation of the pulmonary embolism rule-out criteria.  J Thromb Haemost 2008; 6:772-80.
Kline JA, et al.  Clinical criteria to prevent unnecessary diagnostic testing in emergency department patients with suspected pulmonary embolism.  J Thromb Haemost 2004; 2:1247-55.
Wolf SJ, et al.  Prospective validation of Wells Criteria in the evaluation of patients with suspected pulmonary embolism.  Ann Emerg Med  2004;44(5):503-10.
Wood KE.  Major pulmonary embolism: review of pathophysicologic approach to the golden hour of hemodynamically significant pulmonary embolism.  Chest 2002;121:877-905.
Wells PS, et al.  Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer.  Ann Intern Med  2001;135(2):98-107.

Pneumonia
Huang DT, et al.  Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia.  Ann Emerg Med.  2008;52:48-58.
Charles PGP, et al.  SMART-COP: a tool for predicting the need for intensive respiratory or vasopressor support in community-acquired pneumonia.  Clin Inf Dis.  2008; 47:375-84.
Kennedy M, et al. Do emergency department blood cultures change clinical practice in patients with pneumonia?  Ann Emerg Med 2005;46(5):393-400.
Aujesky D, et al.  Prospective comparison of three validated prediction rules for prognosis in community-acquired pneumonia.  Am J Med 2005; 118:384-392.
Corbo J, et al.  Limited usefulness of initial blood cultures in community acquired pneumonia.  Emerg Med J.  2004;21(4):446-8.
Houck, PM, et al.  Timing of Antibiotic Administration and Outcomes for Medicare Patients Hospitalized with Community-Acquired Pneumonia.  Arch Int Med.  2004;164:637-644.
Meehan, TP, et al.  Quality of Care, Process, and Outcomes in elderly patients with pneumonia.  JAMA.  1997;278:2080-2084.
Fine MJ, et al.  A prediction rule to identify low-risk patients with community acquired pneumonia.  N Engl J Med 1997;336:243-50.
Chalasani NP, et al.  Clinical utility of blood cultures in adult patients with community-acquired pneumonia without defined underlying risk.  Chest.  1995;108(4):932-6.

Asthma/COPD
Camargo CA, et al.  Managing Asthma Exacerbations in the Emergency Department:  Summary of the National Asthma Education and Prevention Program Expert Panel Report 3 Guidelines for the Management of Ashtma Exacerbations.  Proc Am Thor Soc.  2009; 6:357-366.
Rodrigo GJ, et al.  Heliox for non-intubated acute asthma patients.  Cochrane Systematic Reviews  2006, Issue 4.
Lee DL, et al.  Beneficial effects of albuterol therapy driven by heliox versus by oxygen in severe asthma exacerbation.  Acad Emerg Med.  2005;12:820-827.
Denniston AK, et al.  The use of oxygen in acute exacerbations of chronic obstructive pulmonary disease: a prospective audit of pre-hospital and hospital emergency management.  Clin Med.  2002;2:449-51.

Brochard L, et al.  Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease.  NEJM.  1995;333:817-22.

VASCULAR

Thrombosis
Guyatt GH, et al.  Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Pysicians evidence-based clinical practice guidelines.  Chest.  2012; 141(2)(Suppl):7S-47S.       \        Abbreviated version for March Journal Club
Jaff MR, et al.  Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association.  Circulation 2011; 123:1788-1830.

GASTROINTESTINAL

Nausea/vomiting
McGee S, et al.  The rational clinical examination.  Is this patient hypovolemic?  JAMA.  1999; 281(11):1022-9.

TRAUMA

EMS
Newgard CD, et al.  Emergency medical services intervals and survival in trauma:  assessment of the “golden hour” in a North American prospective cohort.  Ann Emerg Med.  2010;55(3):235-246.

Cervical Spine Injury
Leonard JC, et al.  Factors associated with cervical spine injury in children after blunt trauma, PECARN (Pediatric Emergency Care Applied Research Network).  Ann Emerg Med  2010;58:145-155.
Hoffman JR, et al.  Validity of a set of clinical criteria to rule out injury to the cervical spine in patients with blunt trauma, NEXUS (National Emergency X-Radiography Utilization Study Group).   New Engl J Med   2000;343:94-9.

Head Trauma
Kupperman N, et al.  Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study, PECARN (Pediatric Emergency Care Applied Research Network).  Lancet  2009;374:1160-70.

Trauma Resuscitation
Plurad DS, et al.  Early vasopressor use in critical injury is associated with mortality independent from volume status.  J Trauma 2011;71:565-572.
Haukoos JS, et al.  Validation and refinement of a rule to predict emergency intervention in adult trauma patients.   Ann Emerg Med.  2011;58:164-171.
Crash-2 trial collaborators.  Effects of tranexamic acid on death, vascular occusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.  Lancet 2010;376:23-32.
Sloan EP, et al.  Diaspirin Cross-Linked Hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock; a randomized controlled efficacy trial.  JAMA 1999;282:1857-1864.

NEUROLOGY

Stroke
Granger CB, et al.  Apixaban versus warfarin in patients with atrial fibrillation.  New Engl J Med  2011;365:981-92.
Beasley BN, et al.  Anticoagulant options — why the FDA approved a higher but not a lower dose of Dabigatran.  New Engl J Med  2011;364:1789-90.
Perry JJ, et al.  Prospective validation of the ABCD2 score for patients in the emergency department with transient ischemic attack.  CMAJ  2011;183(10):1127-8.
Chernyshev OY, et al.  Safety of tPA in stroke mimics and neuroimaging-negative cerebral ischemia.  Neurology  2010;74:1340-1345.
Ahmed N, et al.  Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITS-ISTR.  Lancet Neurol 2010;9(9):866-74.
Connolly SJ, et al.  Dabigatran versus warfarin in patients with atrial fibrillation.  New Engl J Med  2009; 361:1139-51.
Kattah JC, et al.  HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion weighted imaging.  Stroke 2009;40:3504-10.
Singer DE, et al.  The net clinical benefit of warfarin anticoagulation in atrial fibrillation.  Ann Intern Med  2009;151:297-305.
van Ryn J, et al.  Dabigatran etexilate — a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity.  Thromb Haemost  2010; 103:1116-1127.
Josephson SA, et al.  Higher ABCD2 score predicts patients most likely to have true transient ischemic attack.  Stroke.  2008;39:3096-3098.
Hacke W, et al.  Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.  New Engl J Med  2008;359:1317-29.
Katzan IL, et al.  Use of tissue-type plasminogen activator for acute ischemic stroke: the Cleveland area experience.  JAMA  2000; 283:1151-1158.
Kwiatkowski TG, et al.  Effects of tissue plasminogen activator for acute ischemic stroke at one year.  National Institute of Neurologic Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Study Group.  New Engl J Med 1999;340(23):1781-7.

Meningitis
De Gans J, et al.  Dexamethasone in adults with bacterial meningitis. New Engl J Med 2002;347(20):1549-56.

Spinal Cord Injury
Bracken MB, Holford TR.  Neurological and functional status 1 year after acute spinal cord injury:  estimates of functional recovery in National Acute Spinal Cord Injury Study II from results modeled in National Acute Spinal Cord Injury Study III.  J Neurosurg 2002;96(3 suppl):259-66.
Bracken MB, et al.  Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury: results of the third National Acute Spinal Cord Injury Randomized Controlled Trial — National Acute Spinal Cord Injury Study.  JAMA 1997; 277:1597-1604.
Bracken MB, et al.  A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury, results of the second National Acute Spinal Cord Injury Study.  New Engl J Med  1990; 322:1405-11.

Vertigo
Kattah JC, et al.  HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion weighted imaging.  Stroke 2009;40:3504-10.

Seizure
Kesselheim AS, et al.  Seizure outcomes following the use of generic versus brand-name antiepileptic drugs: a systematic review and meta-analysis.  Drugs. 2010;70(5):605-21.

Subarachnoid hemorrhage
Perry JJ, et al.  Sensitivity of computed tomography performed within six hours of onset of headache for diagnosis of subarachnoid haemorrhage:  prospective cohort study.  BMJ 2011; 343:d4277.

INFECTIOUS DISEASE

Pneumonia
Huang DT, et al.  Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia.  Ann Emerg Med.  2008;52:48-58.
Kennedy M, et al. Do emergency department blood cultures change clinical practice in patients with pneumonia?  Ann Emerg Med 2005;46(5):393-400.
Corbo J, et al.  Limited usefulness of initial blood cultures in community acquired pneumonia.  Emerg Med J.  2004;21(4):446-8.
Houck, PM, et al.  Timing of Antibiotic Administration and Outcomes for Medicare Patients Hospitalized with Community-Acquired Pneumonia.  Arch Int Med.  2004;164:637-644.
Meehan, TP, et al.  Quality of Care, Process, and Outcomes in elderly patients with pneumonia.  JAMA.  1997;278:2080-2084.
Chalasani NP, et al.  Clinical utility of blood cultures in adult patients with community-acquired pneumonia without defined underlying risk.  Chest.  1995;108(4):932-6.

Sepsis
Jones AE, et al.  Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial.  JAMA.  2010;303(8):739-46.
Arnold RC, et al.  Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis.  Shock.  2009;32(1):35-9.
Rivers E, et al.  Early goal-directed therapy in the treatment of severe sepsis and septic shock.   New Engl J Med.  2001;345(19): 1368-77.

Soft Tissue Infections
Moran GJ, et al.  Methicillin-resistant S. aureus infections among patients in the emergency department.  N Engl J Med.  2006;355(7):666-74.
Frazee BW, et al.  High prevalence of methicillin-resistant Staphylococcus aureus in emergency department skin and soft tissue infections.  Ann Emerg Med.  2005;45(3):311-20.

OBSTETRICS & GYNECOLOGY

1st Trimester Bleeding
Everett C.  Incidence and outcome of bleeding before the 20th week of pregnancy: prospective study from general practice.  Br Med J  1997;315(7099):32-4.

SURGERY

Acute Abdominal Pain
Kim K, et al.  Low-dose abdominal CT for evaluating suspected appendicitis.  N Engl J Med 2012;366:1596-605.
Gallagher EJ, et al.  Randomized clinical trial of morphine in acute abdominal pain.  Ann Emerg Med 2006; 48(2):150-60.
Wolfe JM, et al.  Does morphine change the physical examination in patients with acute appendicitis?  Am J Emerg Med 2004; 22(4):280-5.
Thomas SH, et al.  Effects of morphine analgesia on diagnostic accuracy in Emergency Department patients with abdominal pain: a prospective, randomized trial. J Am Coll Surg 2003; 196(1):18-31.

PEDIATRICS

Head Trauma
Kupperman N, et al.  Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study, PECARN (Pediatric Emergency Care Applied Research Network).  Lancet  2009;374:1160-70.

Cervical Spine Injury
Leonard JC, et al.  Factors associated with cervical spine injury in children after blunt trauma, PECARN (Pediatric Emergency Care Applied Research Network).  Ann Emerg Med  2010;xx:xxx.  (article in press)

ENVIRONMENTAL

TOXICOLOGY

Carbon Monoxide Poisoning
Weaver LK, et al.  Hyperbaric-oxygen for acute carbon monoxide poisoning.  New Engl J Med.  2002 347(14):1057-67.
Thom SR.  Hyperbaric-oxygen therapy for acute carbon monoxide poisoning (comment).  New Engl J Med.  2002 347(14):1057-67.

Tylenol
Wolf SJ, et al.  Clinical policy: critical issues in the management of patients presenting to the emergency department with acetaminophen overdose.  Ann Emerg Med.  2007 50(3):292-313.
Rumack BH, et al.  Acetaminophen overdose.  662 cases with evaluation of oral acetylcysteine treatment.  Arch Intern Med.  1981;141:380-5.

Tricyclic Antidepressants
Liebelt EL, et al.  ECG lead aVR versus QRS interval in predicting seizures and arrhythmias in acute tricyclic antidepressant toxicity.  Ann Emerg Med.  1995;26:195-201.

Cocaine
Weber JE, et al.  Validation of a brief observation period for patients with cocaine-associated chest pain.  New Engl J Med.  2003; 348(6):510-7.

Digoxin
Bismuth C, et al.  Hyperkalemia in acute digitalis poisoning: prognostic significance and therapeutic implications.  Clin Tox.  1973; 6(2): 153-162.

Undifferentiated Poisoning
Manini AF, et al.  Electrocardiographic predictors of adverse cardiovascular events in suspected poisonings.  J Med Tox.  2010;6:106-115.

MUSCULOSKELETAL

DERMATOLOGICAL

Soft Tissue Infections
Moran GJ, et al.  Methicillin-resistant S. aureus infections among patients in the emergency department.  N Engl J Med.  2006;355(7):666-74.
Frazee BW, et al.  High prevalence of methicillin-resistant Staphylococcus aureus in emergency department skin and soft tissue infections.  Ann Emerg Med.  2005;45(3):311-20.

HEMATOLOGY/ONCOLOGY

Sickle Cell
Aisiku IP, et al.  Comparison of High Versus Low Emergency Department Utilizers in Sickle Cell Disease.  Ann Emerg Med.  2009;53:587-593.

ENT

Acute Otitis Media
Hoberman A, et al.  Treatment of acute otitis media in children under 2 years of age.  N Engl J Med 2011;364:105-15.

Sinusitis
Garbutt JM, et al.  Amoxicillin for acute rhinosinusitis, a randomized controlled trial.  JAMA 2012;307(7):685-692.

RADIOLOGY
Kim KS, et al.  Risk stratification nomogram for nephropathy after abdominal contrast-enhanced computed tomography.  Am J Emerg Med  2011;29:412-417.
Mitchell AM, et al.  Immediate complications of intravenous contrast for computed tomography imaging in the outpatient setting are rare.  Acad Emerg Med 2011; 18:1005-1009.



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